盐酸鲁拉西酮 盐酸卢拉西酮 罗西酮盐酸盐CAS: 367514-88-3原料仅供出口或科研试验

中文名罗西酮盐酸盐
英文名(3ar,4s,7r,7as)-2-[(1r,2r)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-1h-4,7-methanoisoindole-1,3-dionehydrochloride
别名盐酸鲁拉西酮
盐酸卢拉西酮
罗西酮盐酸盐
鲁拉西酮盐酸盐
外二烯卢拉西酮
罗拉西酮盐酸盐
盐酸鲁拉西酮(罗西酮盐酸盐)
盐酸鲁拉西酮-罗拉西酮盐酸盐
盐酸卢拉西酮lurasidonhydrochloride
英文别名lurasidonehcl
exodienelurasidone
lurasidonhydrochlorid
lurasidonhydrochloride
lurasidonehydrochloride
lurasidonehydrochloride
lurasidone hydrochloride tablets
(3ar,4r,7s,7as)-2-(((1r,2r)-2-((4-(benzo[d]isothiazol-3-yl)
(3ar,4s,7r,7as)-2-[(1r,2r)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-1h-4,7-methanoisoindole-1,3-dionehydrochloride
(3ar,4s,7r,7as)-2-(((1r,2r)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1h-4,7-methanoisoindole-1,3(2h)-dionehydrochloride
(3ar,4s,7r,7as)-2-[[(1r,2r)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1h-isoindole-1,3(2h)-dionehydrochloride
4,7-methano-1h-isoindole-1,3(2h)-dione,2-[[(1r,2r)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-,(3ar,4s,7r,7as)- hydrochloride
cas367514-88-3
einecs682-423-6化学式c28h36n4o2s
分子量492.684inchikeypjibdqsa-n熔点198-205°c闪点9℃存储条件refrigerator体外研究lurasidone剂量依赖性拮抗多巴胺刺激的人多巴胺d2l受体上[35s]gtpγs结合，kb 值为2.8nm。lurasidone拮抗cho/h5-ht7细胞中5-ht刺激的camp积累，kb值为2.6nm。lurasidone部分刺激[35s]gtpγs结合到人5-ht1a受体的膜制剂上，大作用为33%。lurasidone剂量依赖性增加大鼠额叶皮层和纹状体中dopac/多巴胺比率。