10-羟基喜树碱CAS: 64439-81-2;19685-09-7分析纯 工业级 科研试剂 全国送货 一瓶起售

中文名(S)-10-羟基喜树碱
英文名(s)-10-hydroxycamptothecin
别名羟基喜树碱
10-羟基喜树碱
(S)-10-羟基喜树碱
(20S)-10-羟基喜树碱
10-(±)羟基喜树碱标准品
英文别名160177
10-HCPT
Hydroxycamptothecin
Hydroxy Camptothecine
Hydroxy camptothecine
10-Hydroxycamp-totecin
10-hydroxycamptothecin
10hydroxy camptothecin
10-hydroxy camptothecin
7ETHYHYDROXYCAMPTOTHECIN
7-ethy hydroxycamptothecin
(s)-10-hydroxycamptothecin
10-HYDROXYCAMPTOTHECIN ACETATE
7-ETHYL-10-HYDROXY CAMPTHOTECIN
77-Ethyl-10-hydroxy campthotecin
10-HYDROXYCAMPTOTHECIN ACETATE SALT
(20S)- 7-Ethyl-10-Hydroxycamptothecin
CAS64439-81-2
19685-09-7
EINECS613-598-9化学式C20H16N2O5
分子量364.35InChIInChI=1/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1InChIKeyLCZZWLIDINBPRC-F密度1.60熔点230-237°C沸点820.7±65.0 °C(Predicted)闪点450.1°C蒸汽压1.67E-28mmHg at 25°C溶解度不溶于水，溶于稀碱溶液，难溶于甲醇、氯仿、，微溶于甲醇-氯仿混合溶剂。折射率1.776酸度系数8.93±0.40(Predicted)存储条件Keep in dark place,Inert atmosphere,Store in freezer, under-20°C外观淡黄色粉末物化性质Appearance: Yellow crystal
melting point: 268 ℃~270 ℃
MDL号MFCD02093100体外研究(±)-10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor oftopo I. (±)-10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedlyinhibits the proliferation of Colo 205 cells in a dose-dependentmanner. (±)-10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cellsin the G2 phase of the cell cycle and triggers apoptosis through acaspase-3-dependent pathway. (±)-10-Hydroxycamptothecin (HPT,0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation andcondensed chromosomes and induces apoptosis of human urinarybladder cancer cell line (T24).体内研究(±)-10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.)significantly suppresss tumor growth in mouse xenografts.(±)-10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4days) causes no obvious acute toxicity in nude mice.危险品标志Xi - 刺激性物品

T - 有毒物品

风险术语R36/37/38 - 刺激眼睛、呼吸系统和皮肤。
R25 - 吞食有毒。
安全术语S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S36 - 穿戴适当的防护服。
S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
危险品运输编号UN 2811 6.1 / PGIIIWGK Germany3RTECSU参考资料 

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1. 邢志华, 方桂珍. 离子交联法制备叶酸-壳聚糖微球工艺研究[J]. 黑龙江医药, 2011, 24(6):915-917.2.邢志华, 方桂珍, 苏玲,等. 羟基喜树碱叶酸-壳聚糖纳米粒的制备及其性能研究[J]. 功能材料, 201...