| CAS | 120-46-7 |
| EINECS | 204-398-9 |
| 化学式 | C15H12O2 |
| 分子量 | 224.25 |
| InChI | InChI=1/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-11,16H/b14-11- |
| InChIKey | NZZIMKJIVMHWJC-UHFFFAOYSA-N |
| 密度 | 0.800 g/cm3 |
| 熔点 | 77-79°C(lit.) |
| 沸点 | 219-221°C18mm Hg(lit.) |
| 闪点 | 219-221°C/18mm |
| 水溶性 | It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water. |
| 蒸汽压 | 0.01Pa at 20℃ |
| 溶解度 | 氯仿 (微溶) 、甲醇 (微溶，超声处理) |
| 折射率 | 1.6600 (estimate) |
| 酸度系数 | 8.95±0.10(Predicted) |
| 存储条件 | Store below +30°C. |
| 稳定性 | 稳定。与强氧化剂不相容。 |
| 外观 | 晶体 |
| 颜色 | Light yellow to yellow |
| Merck | 14,3009 |
| BRN | 514910 |
| 物化性质 | 无色斜方形片状结晶。熔点81℃，沸点219℃（2.4kPa）。易溶于氯醇、氯仿，能溶于氢氧化钠溶液，不溶于碳酸钠溶液，极微溶于水。 |
| MDL号 | MFCD00003085 |
| 体外研究 | Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h. Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells. Dibenzoylmethane does not show significant cytotoxicity. |
| 体内研究 | Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice. Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice. |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| RTECS | TZ1930000 |
| TSCA | Yes |
| 海关编号 | 29143900 |
| Hazard Note | Irritant |
丙酸 ; 甲酸 ; 磷酸 ; 乳酸 ; 四氢呋喃 ; 二氯甲烷 ; 硝 酸 ; 硫 酸 ; 盐 酸 ; 过氧 化 钠 ; DMF ; DMAC ; EDTA二钠 ; EDTA四钠
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