MASH1 PURE MAB

description

mash1 and mash2 (mammalian achaete-schutehomolog 1 and 2) are basic helixloop-helix transcription factorswhich are mammalian homologs of the achaete-schute genefamily that is required for neuronal development in drosophila. thebhlh motif is present in many types of transcription factorsincluding e2-2, e47, myod and others. mash1 has been shown toheterodimerize with other bhlh containing transcription factors.mash1-e12 heteromers bind to and promote transcriptional activationof muscle creatine kinase, a known target for myod activation.however, mash1 appears to play its primary role during earlydevelopment of the autonomic nervous system. in committed neuronalprecursor cells, early expression of mash1 activates a subset ofneuron-specific genes to promote differentiation. thus nullmutations in the mash1 gene suggest that mash1 is a valuable markerfor investigation of neural development in mammals. mash1 isobserved as an ~34 kda protein by sds-page.

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