中文名人参皂甙 Rb3 英文名ginsenoside rb3 别名红茶浸膏粉 人参皂苷Rb3 人参皂荚RB2 人参皂甙 Rb3 人参皂甙 RB3 人参皂苷 Rb3 人参皂苷RB3对照品, 人参皂苷RB3(标准品) 人参皂苷RB3(人参皂荚RB2 人参皂苷 RB3, 来源于人参 GINSENOSIDE RB3 人参皂甙 RB3 英文别名Gypenoside IV xylopyranosyl- ginsenoside rb3 Ginsenoside Rb3 GINSENOSIDE Rb3(SH) hydroxydammar-24-en-20-yl6-O-β-D- β-D-Glucopyranoside, (3β,12β)-3-[(2-O-β-D- glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl6-o-beta-d-xylopyranosyl- [3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-12β-hydroxy-5α-dammar-24-en-20-yl]6-O-(β-D-xylopyranosyl)-β-D-glucopyranoside alpha-D-Glucopyranoside, (3-beta,12-beta)-3-((2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl 6-O-beta-D-xylopyranosyl- (1R,4E)-1-{(8xi,9xi,12α,13xi,14β)-3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxy-4,4,10,14-tetramethylgonan-17-yl}-1,5-dimethylhept-4-en-1-yl 6-O-β-D-xylopyranosyl-β-D-allopyranoside CAS68406-26-8 化学式C53H90O22 分子量1079.27InChIInChI=1/C53H90O22/c1-8-23(2)10-9-15-53(7,75-48-44(67)40(63)38(61)31(72-48)22-69-46-42(65)35(58)28(57)21-68-46)25-13-16-52(6)24-11-12-32-50(3,4)33(14-17-51(32,5)26(24)18-27(56)34(25)52)73-49-45(41(64)37(60)30(20-55)71-49)74-47-43(66)39(62)36(59)29(19-54)70-47/h10,24-49,54-67H,8-9,11-22H2,1-7H3/b23-10+/t24?,25?,26?,27-,28+,29+,30+,31+,32?,33?,34?,35-,36+,37+,38+,39-,40+,41-,42+,43+,44+,45+,46-,47-,48-,49-,51+,52+,53+/m0/s1密度1.42±0.1 g/cm3(Predicted)熔点193～195℃沸点1117.1±65.0 °C(Predicted)比旋光度(c, 1 in MeOH)+19.4闪点634.2°C蒸汽压0mmHg at 25°C溶解度DMSO (微溶) 、甲醇 (微溶) 、吡啶 (微溶)折射率1.621酸度系数12.85±0.70(Predicted)存储条件Sealed in dry,2-8°C稳定性吸湿性敏感性Easily absorbing moisture外观整洁颜色White物化性质白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于人参，绞股蓝。MDL号MFCD10566396体外研究Ginsenoside Rb3 (0.1-10 μM) is tested for inhibition of tumor necrosis factor-α (TNF)-induced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) luciferase reporter activity using a human kidney 293T cell-based assay. Ginsenoside Rb3 shows the significant activity with an IC 50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) messenger Ribonucleic acid (mRNA) in a dose-dependent manner after HepG2 cells have been treated with TNF-α (10 ng/mL). Ginsenoside Rb3 (0.1-10 μM) significantly increases cell viability and inhibits lactate dehydrogenase (LDH) release in a dose-dependent manner. PC12 cell viability as determined by MTT reduction is also markedly decreased after the cell is exposed to oxygen and glucose deprivation (OGD)/OGD-Rep. But, when the cells are pretreated with Ginsenoside Rb3 (0.1, 1, and 10 μM), OGD/OGD-Rep induced cell toxicity is significantly attenuated, which is concentration-dependently attenuated by Ginsenoside Rb3 treatment. The viabilities are raised to 52.8%±5.6%, 64.6%±5.7%, and 76.4%±8.8%, respectively, compared with the control group.体内研究Ginsenosides Rb3 is a major compound isolated from Gynostemma pentaphyllum that holistically improves gut microenvironment and induces anti-polyposis in Apc Min/+ mice. Six-weeks-old mice are subjected to Rb3 treatment, before the appearance of the intestinal polyps. All the mice are monitored for food intake, water consumption, and weight changes. Throughout the experiment, no Rb3/Rd-associated weight loss in mice is observed. In addition, none of the treated mice show variations in food and water consumption. Whereas, the number and size of the polyps are effectively reduced by Rb3 treatments.安全术语24/25 - 避免与皮肤和眼睛接触。 WGK Germany3RTECSLZ5857000海关编号29389090参考资料
