中文名水合加替沙星 英文名Gatifloxacin ses 别名水合加替沙星 加替沙星水合物 加替沙星羧酸乙酯 1-环丙基-6-氟-4-氧代-8-甲氧基-7-(3-甲基 1-环丙基-6-氟-8-甲氧基-7-(3-甲基哌嗪-1-基)-4-氧代3-喹啉羧酸 1-环丙基-6-氟-8-甲氧基-7-(3-甲基哌嗪-1-基)-4-氧代-3-喹啉羧酸 1-环丙基-6-氟-8-甲氧基-7-(3-甲基-1- 哌嗪)-4-氧代-喹啉-3-羧酸 1-环丙基-6-氟-8-甲氧基-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢3-喹啉羧酸 英文别名(+-)-1-C Gatifloxacin (300 mg) Gatifloxacin Monohydrate Gatifloxacin ses Gatifloxacin formic acid ethyl ester 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-ic acid Gatifloxcin 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-3-ic acid 1-Cyclopropyl-6-fluoro-8-Methoxy-7-(3-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroxylic acid ses CAS180200-66-2 EINECS672-577-2化学式C19H24FN3O5 分子量393.42沸点684℃溶解度溶于1N NaOH，浓度为10mg/ml存储条件Keep in dark place,Inert atmosphere,2-8°C外观整洁BRN14390028体外研究Gatifloxacin ses is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with IC 50 values of 13.8 μg/ml, 0.109 μg/ml, and 265 μg/ml, respectively.Gatifloxacin ses is against S. aureus MS5935 topoisomerase IV, E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with MIC values of 0.05 μg/ml, 0.0063 μg/ml, and 122 μg/ml, respectively.Gatifloxacin ses exhibits antibacterial activities for wild-type strains (MS5935, MS5952, MR5867 and MR6009) the first-, second-, third-, and fourth-step mutants with MIC values of 0.05 to 0.10 μg/ml, 0.20 μg/ml, 1.56 to 3.13 μg/ml, 1.56 to 6.25 μg/ml, and 50 to 200 μg/ml, respectively. Gatifloxacin ses displays the most potent activity against the second- and third-step mutants (MS5952, MR5867 and MR6009) except for the second-step mutant of strain MS5935.Gatifloxacin ses has potent activity against norA transformant NY12 (MIC, 0.39 μg/ml).Gatifloxacin ses (20-100 μM; 72 hours) significantly decreases insulin content to 60% at Day 1, and continues to be reduced to 50.1% and 44.7% at Day 3 by 20 μM and 100 μM Gatifloxacin ses, respectively.危险品标志Xn - 有害物品 风险术语20/21/22 - 吸入、皮肤接触及吞食有害。 安全术语36/37 - 穿戴适当的防护服和手套。 WGK Germany1RTECSVB1983600
