详细介绍
中文名氯哌斯汀芬地柞酸盐
英文名o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compoundwith 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
别名氯哌酮芬地唑
氯哌斯汀芬地柞酸
氯哌斯汀芬地柞酸盐
氯苄哌醚联苯酰苯酸盐
化合物 t13619
1-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐
英文别名cloperastinefebdizoate
cloperastinefendizoate
levocloperastinefendizoate
levocloperastine fendizoate racemic impurity
1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]piperidinefendizoate
1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoicacid
cas85187-37-7
einecs286-126-9化学式c40h38clno5
分子量648.18642inchiinchi=1/c20h24clno.c20h14o4/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;21-18-11-10-14(12-17(18)13-6-2-1-3-7-13)19(22)15-8-4-5-9-16(15)20(23)24/h1,3-4,7-12,20h,2,5-6,13-16h2;1-12,21h,(h,23,24)熔点185-187°c沸点593.9°c at 760 mmhg闪点327°c蒸汽压5.95e-15mmhg at 25°c溶解度dmso (微溶) 、甲醇 (微溶)存储条件hygroscopic, -20°c freezer, under inert atmosphere稳定性吸湿性外观固体颜色white to off-white体外研究cloperastine inhibits the herg k + currents in aconcentrationdependent manner with ic 50 value of 27±3 nm. amongthe antitussive agents, cloperastine, which possesses antitussiveand antiedemic activity, also relaxes the bronchial musculature.cloperastine is a drug with a central antitussive effect, and isalso endowed with an antihistaminic and papaverine-like activitysimilar to codeine but without its narcotic effects.体内研究in the anesthetized guinea pigs, cloperastine at a therapeutic doseof 1 mg/kg prolonged the qt interval and monophasic actionpotential (map) duration without affecting pr interval or cloperastine hydrochloride shows relatively low acutetoxicity when administered by the intraperitoneal route in rats andmice, and shows minor toxicity by the oral route when administeredas cloperastine fendizoate, the ld 50 in rats and mice for the twoadministration routes exceeds 1000 and 2000 mg/kg,respectively.
仅供科研实验或出口
