布帕伐琨 布帕伐醌CAS: 88426-33-9原料仅供出口或科研试验

中文名布帕伐醌
英文名uone
别名布帕伐琨
布帕伐醌
单晶冰糖
uone 布帕伐醌
2-[(4-叔丁基环己基)甲基]-3-羟基-1,4-萘二酮
2-((4-(叔丁基)环己基)甲基)-3-羟基萘-1,4-二酮
英文别名bw-720c
cs-1178
butalex
uone
uone-d4
2-((4-tert-butylcyclohexyl)methyl)-3-hydroxy-1,uinone
2-((4-tert-butylcyclohexyl)methyl)-3-hydroxynaphthalene-1,4-dione
2-[(4-tert-butylcyclohexyl)methyl]-3-hydroxynaphthalene-1,4-dione
3-[(4-tert-butylcyclohexyl)methyl]-4-hydroxynaphthalene-1,2-dione
2-((4-(1,1-dimethylethyl)cyclohexyl)methyl)-3-hydroxy-4-naphthalenedione
2-[[4-(1,1-dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione
cas88426-33-9
einecs618-162-1化学式c21h26o3
分子量326.43inchiinchi=1/c21h26o3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,24h,8-12h2,1-3h3密度1.158±0.06 g/cm3(predicted)熔点178-184°c沸点460.7±45.0 °c(predicted)闪点246.536°c蒸汽压0mmhg at 25°c溶解度dmso: soluble折射率1.574酸度系数5.04±0.10(predicted)存储条件sealed in dry,2-8°c外观powder颜色yellow体外研究in 4-day proliferation assays, uone efficiently inhibitsn. caninum tachyzoite replication(ic 50 =4.9 nm; ic 100 =100 nm).uone is significantly selective against l. (l.) infantumchagasi intracellular amastigotes, with an ic 50 value of 1.5 μm.other cutaneous species are also susceptible to uone, withic 50 values in the range 1-4 μm.体内研究uone具有较长的血浆半衰期（至少7天）和低毒性作用（在大鼠中口服ld50大于8000 mg/kg）。