氟米松(flumethasone) CAS: 2135-17-3原料供应仅供科研实验或出口

中文名氟米松
英文名flumethasone
别名氟美松
氟米松
双氟美松
福如迈塔松
氟米松(氟美松
6Α-氟地塞米松
氟米松(标准品)
氟米松溶液,100ppm
英文别名flumethasone
6α-fluorodexamethasone
6α,9α-difluoro-16α-methylprednisolone
6a-fluoro-dexamethasone, aniprime, cortexilar, flucort
6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
6α,9α-difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
(6alpha,11beta,16alpha)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
(6-alpha,11-beta,16-alpha)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
6-alpha,9-alpha-difluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
(6alpha,8xi,11beta,14xi,16alpha)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
pregna-1,4-diene-3,20-dione,6,9-difluoro-11,17,21-trihydroxy-16-methyl-,(6.alpha.,11.beta.,16.alpha.)-
cas2135-17-3
einecs218-370-9化学式c22h28f2o5
分子量410.45inchiinchi=1/c22h28f2o5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29h,6,8-10h2,1-3h3/t11-,13?,14?,16+,17+,19+,20+,21+,22+/m1/s1inchikeyyhhcasa-n密度1.1621 (estimate)熔点237-240°c沸点569.8±50.0 °c(predicted)比旋光度[α]25/d 67.0 to 71.0°, c = 1 in dioxane闪点298.4°c水溶性1mg/l(20 ºc)蒸汽压2.33e-15mmhg at 25°c溶解度acetic acid: soluble10mg/ml折射率1.579酸度系数11.98±0.70(predicted)存储条件2-8°c外观solid颜色whitemerck14,4138mdl号mfcd00056464体内研究flumethasone (0.5 mg/100 kg 体重)处理小牛24小时后，降低胰岛素依赖的葡萄糖利用。flumethasone 与 sodiumceftiofur联用处理患严重急性支气管肺炎小牛，降低了死亡率，及临床和血液学参数，恢复到正常水平，显著快于对照组小牛。flumethasone (5 mg) 处理患酮症的小牛，对子宫疾病的恢复具有显著作用。flumethasone (5 mg)处理患酮症的小牛，增加血浆葡萄糖浓度，降低血清β-羟基丁酸和尿乙酰乙酸浓度。虽然在大多数情况下，实验组动物中的flumethasone水平一般高于检测限，但dexamethasone处理的小牛中，flumethasone浓度低于相应的糖皮质激素水平。在小牛尿样中也可检测到flumethasone。flumethasone结合血浆皮质素传递蛋白，当它未结合到皮质素传递蛋白是激活状态。