牛甲状旁腺激活素CAS: 12583-68-5实验室定制供应发货

中文名牛甲状旁腺激活素-(1-34)
英文名parathyroid hormone (1-34), bovine
别名特立帕肽-多肽原料委托生产
特立帕肽-多肽制剂一致性评价
牛甲状旁腺激素-(1-34)
牛甲状旁腺激活素-(1-34)
pht激活剂(teriparatide)
受体激动剂多肽parathyroid hormone(1-34) bovine
英文别名bpth1-34
teriparatide
pth (1-34)(bovine)
parathyroid hormone (1-34), bovine
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h-ala-val-ser-glu-ile-gln-phe-met-his-asn-leu-gly-lys-his-leu-ser-ser-met-glu-arg-val-glu-trp-leu-arg-lys-lys-leu-gln-asp-val-his-asn-phe-oh
ala-val-ser-glu-ile-gln-phe-met-his-asn-leu-gly-lys-his-leu-ser-ser-met-glu-arg-val-glu-trp-leu-arg-lys-lys-leu-gln-asp-val-his-asn-phebovine
cas12583-68-5
化学式c183h288n54o50s2
分子量4108.71存储条件−20°c外观powder体外研究parathyroid hormone (1-34), bovine (0.1-100 ng/ml; 2-20 days) areadded to the medium, it inhibits osteoblast proliferation in adose-dependent manner. in another group, bpth are added to theculture medium from day 1 to day 10, but not from days 11 to 20, arebound of proliferation is observed in the pth day 1–10 groupafter bpth withdrawal.parathyroid hormone (1-34), bovine (0.1-100ng/ml; 2-20 days) induces diverse effects on the calcium andphosphorus content of culture medium. the calcium and phosphoruscontent of culture medium in the pth-c 100 ng/ml group are higherthan in teh control group. cell proliferation assay cell line:mc3t3-e1 cells concentration: 0.1-100 ng/ml incubation time: 2-20days result: resulted a decrease of osteoblast proliferationinconcentration-dependent manner. resulted in a rebound ofproliferation when pth withdrawal.体内研究parathyroid hormone (1-34)(subcutaneousinjection; 80 μg/kg; 5 days)increases serum osteocalcin concentrations without changing seruminorganic phosphate or calcium concentrations in either group ofold animals.serum 1,25-dihydroxyvitamin d concentrations aresignificantly higher in the pth-treated senile female rats than thesex-matchedvehicle-treated controls.