进口杜笙固相肽合成 Merrified离子交换树脂

products for solid phase peptide synthesis/combinatorialchemistry
tulsion®cmbpolymers提供固相合成肽生物科技
特麦仕制造特殊等级的杜笙 polymers 用于生物科技固相法的肽合成步骤使用。
thermax make  ecial tulsion® polymers having applications in the biotechnologyarea specially for solid phase peptide synthesis .
杜 笙 cmb 高分子树脂具有能应用于肽的合成的甲基氯官能基.以此种树脂用来合成肽的技术是由merrified于1963年发明。肽的化学键的行成是由此种树脂的官能基与氨基酸键结合而来。在去除保护的官能基之后，一个个新的氨基酸分子便产生来增加其肽的化学键。此肽的化学键的增长是一步一步合成而来的。在每个步骤中过滤掉多余的反应剂。在zui后的合成步骤是去除所有的保护官能基并将肽从此树脂中分离出来。此种树脂的特性可以根据客户需要制造，用来适用不同的合成步骤。它们根据严格的质量标准在非常认真的控制条件下制造。

tulsion® cmb polymershave chloromethyl functionality and are used for peptidesynthesis.use of such polymers for peptide synthesis was initiatedby merrifield in 1963. the formation of peptide bond starts withreaction of a protected amino acid molecule with chloromethyl groupon the surface of the polystyrene polymer. after removal of theprotecting group, a new amino acid molecule is reacted to elongatethe peptide chain. the elongation is continued with stepwiseaddition. excess reagents and byproducts are removed by filtrationat each step. the final step in the synthesis involves freeing upof the protecting group as well as liberating the peptidefrom thepolymer. properties of the polymers can be tailor-made to suitindividual application needs.

they are made under very carefully controlled conditions usingstrictest standards.

tulsion® cbpolymers:

所有高分子合成的基础是聚合物基质。tulsion® cb 100 /200
是zui常用的型号。固相有机合成的zui重要考虑因素是树脂的颗粒大小及膨胀因素。而膨胀因素是由树脂本身的键结程度,水合以及物质的特性有关。
tulsion®cb 100 / 200本身特质具有很好的疏水特性并且在非极性的溶剂中膨胀。他们用于固相的有机合成与dvb 产生交叉键结而具有稳定的机械结构.

the foundation of all polymeric synthesis is the polymeric matrix.tulsion®cb 100 / 200 iscommonly used resin. the most important characteristics consideringsolid phase organic synthesis are the swelling factor and the beadsize of the resin. the swelling characteristics areaffected by thefactors such as degree of crosslinking, hydrophobisity of substrateand nature ofthe matrix.

tulsion® cb 100 / 200itself is very hydrophobic in nature and swells in a non-polarsolvent. it is used in solid phase organic chemistry is crosslinkedwith dvb to give mechanically stable matrix in presence of swellingsolvents.

tulsion®cb 100 / 200树脂能用于各种合成反应，在反应中作为甲基氯树脂或merrifield 树脂(tulsion®cmb) ,wang resins, 或者其他用于固相肽合成的树脂。

tulsion®cb 100 / 200resins are used in variety of reactions to give chloromethyl resinsor merrifield resins (tulsion®cmb), wangresins chlorotrytil resins and other resins used in solidphasepeptide synthesis.

技术资料

technical characteristics -

tulsion®

cmb 100

cmb 200

cb 100

cb 200

结构

matrix structure

交联聚苯乙烯

crosslinked polystyrene

交联聚苯乙烯

crosslinked polystyrene

交联聚苯乙烯

crosslinked polystyrene

交叉键结高分子crosslinked polystyrene

官能基

functional  group

氯甲基

chloromethyl

fb(free base) . 自由基

苯氛

plane polystyrene

苯氛

plane polystyrene

颗粒大小

particle size  (astm)

100 – 200

200 – 400

100 – 400

200 - 400

总氯含量
total chloride content

(meq/dry gm)

0.8 – 0.4

4 – 0.4

-

-

zui大含水量 , %moisture content max

1

1

1

1

溶解率

solubility

不溶于所有的溶剂

insoluble in all solvent

不溶于所有的溶剂

insoluble in all solvent

不溶于所有的溶剂

insoluble in all solvent

不溶于所有的溶剂

insoluble in all solvent

特性

features

颗粒状

free flowing spherical beads

颗粒状

free flowing spherical beads

颗粒状

free flowing spherical beads

颗粒状

free flowing spherical beads